Adding a certain compound to certain chemical reactions, such as: 622392-04-5, name is 2-Bromo-5-iodopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622392-04-5, category: Pyrazines
Add 30 g of 2-bromo-5-iodopyrazine, 300 ml of toluene to a 500 ml three-necked flask.Displace nitrogen protection and then add 26.7 ml of hexa-butyltin di-tin.After the reaction solution was stirred at room temperature for 3 hours,0.61 g of tetrakis(triphenylphosphine)palladium was added, and the mixture was heated to 120 C and stirred for 8 hours.The TLC monitors the complete reaction of the starting material to stop the reaction.After the reaction solution is cooled to room temperature, the column removes insoluble impurities.The crude product obtained after concentration of the eluent was recrystallized from toluene to yield 12.6 g of white solid.The yield was 76.2%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-iodopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Xi’an Ruilian New Materials Co., Ltd.; Zhang Hongke; Sun Jun; Liu Kaipeng; Wang Xiaowei; Liu Qianfeng; Gao Renxiao; Cai Liang; Yang Yan; (34 pag.)CN109053696; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem