Adding a certain compound to certain chemical reactions, such as: 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41270-66-0, Recommanded Product: 5-Chloro-2,3-diphenylpyrazine
5 gm of 2-chloro-5,6-diphenylpyrazine (IV) in 25 ml N-Methyl-2-pyrrolidone (NMP) and 5.18 gm of K2CO3 were mixed with 9.92 gm of 4-(isopropylamino)-l-butanol (III), the reaction mixture was then heated with stirring at 150-155 C for 20-21 hrs. The reaction solution was air-cooled, poured into 25 ml water, extracted with 20 ml ethyl acetate. Aqueous layer washed with 10 ml ethyl acetate. Ethyl acetate layers are combined and washed with 15 ml of water, dried over anhydrous magnesium sulfate and then concentrated to obtain 6.3 gm of residue. 6 gm of the residue was purified by silica gel column chromatography by eluting with 2000 ml hexane and 550 ml ethyl acetate to obtain solid 3.2 gm of the desired compound. Yield: 49.41 %
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Reference:
Patent; LUPIN LIMITED; RAY, Purna, Chandra; KUMAR, Gaurav; SHABADE, Samir, Shanteshwar; RASHINKAR, Dattatray, Bajirao; ARORA, Surinder, Kumar; SINGH, Girij, Pal; (23 pag.)WO2017/60827; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem