Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 1245644-42-1
General procedure: [0194] 6-bromo-3-iodo-imidazo[1,2-a]pyrazine 17* (0.648 g, 2 mmol) was added to a degassed mixture of dioxane(10 ml) and water (1.5 ml). The aromatic boronic acid (R2B(OH)2) (2.2 mmol) was added followed by palladium acetate(0.022 g, 5 mol%), triphenyl phosphine (0.025 g, 5 mol%) and sodium carbonate (0.32 g, 3 mmol). The reaction mixturewas stirred at 80 C under nitrogen for 18 hours. The solvent was evaporated in vacuo and the residue was partitionedbetween water (20 ml) and dichloromethane (50 ml). The dichloromethane was separated, dried over magnesium sulphateand evaporated in vacuo. The residue was purified by flash chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem