Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6294-70-8, name is 5,6-Dimethylpyrazin-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 6294-70-8
At room temperature,Potassium tert-butoxide (5.60 g, 50 mmol)To a solution of 5,6-dimethylpyrazin-2-amine (1.23 g, 10 mmol)In 250 ml of dry THF.After stirring for 15 minutes,2-Nitrothiazole-4-carbonyl chloride (2.10 g, 11 mmol)In 50 ml of dry THF.The reaction mixture was stirred for 4 hours at room temperature,Then poured into saturated aqueous NaHCO 3 solution and extracted with EtOAc.The organic phase was washed with saturated aqueous NaCl solution,Dry over anhydrous Na2SO4 and concentrate to dryness.After purification by silica gel flash chromatography (cyclohexane / EtOAc: 90/10 to 50/50)Obtained as a white solid1.69 g of N- (5,6-dimethylpyrazin-2-yl) -2-nitrothiazole-4-amide(Yield: 61.0%).
The synthetic route of 6294-70-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mudanjiang Medical School; Liu Shijuan; Hou Jiafu; Li Xuemei; Zhou Xue; Wu Yiyan; Zhao Cong; Tong Lei; Zhang Chaoli; Liu Jiawei; Cui Xinyu; (11 pag.)CN107056819; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem