Electric Literature of 914452-71-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914452-71-4 as follows.
To a solution of 2-chloro-4-phenoxypyrrolo[2,1-J][1,2,4]triazine (100 mg, 0.407 mmol), 2-bromo-6-methylpyrazine (70.4 mg, 0.407 mmol) and hexamethylditin (0.084mL, 0.407 mmol) in 1,4-dioxane (7 mL) was added tetrakis(triphenylphosphine)palladium(0) (47.0 mg, 0.041 mmol). The reaction mixture was degassed with argon and was stirred at 100 C for 18 h. The solvent was removed under reduced pressure to get a brown solid. The crude residue was purified by silica gel chromatography (ethyl acetate:Petroleum ether, 10/90) to obtain 2-(6-methylpyrazin-2-yl)-4-phenoxypyrrolo[2,1-J][1,2,4]triazine (85 mg, 0.280 mmol, 68.8 % yield). LCMS m/z 304.4 (M+H); rt 1.45 mm; Conditions B.
According to the analysis of related databases, 914452-71-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARIKRISHNAN, Lalgudi S.; FINK, Brian E.; BORZILLERI, Robert M.; TONUKUNURU, Gopikishan; RAHAMAN, Hasibur; WARRIER, Jayakumar Sankara; SESHADRI, Balaji; (411 pag.)WO2017/15425; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem