Adding a certain compound to certain chemical reactions, such as: 61655-77-4, name is 2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61655-77-4, HPLC of Formula: C9H13ClN4
EXAMPLE 87: 5-(6-(4-methylpiperazin-l-yl)pyrazin-2-yl)-lH-pyrrolor2,3-b1pyridineThe starting material 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrrolo[2,3-b]pyridine (124) (50 mg, 0.2 mmol, 1 eq) and 2-chloro-6-(4-methylpiperazin-l-yl)pyrazine (63) (44 mg, 0.2 mmol, 1 eq) in DMF (5 mL) was degassed and purged under argon atmosphere for 10 min. To this reaction mixture was charged Cs2C03 (133 mg, 0.4 mmol, 2 eq) followed by addition of Pd(PPh3)4 (0.01 mg, 0.04 mmol) and degassing and purging under argon for an additional 10 min. The reaction mixture was heated at 100C for 12 h in a sealed tube. After completion of the reaction, the reaction mixture was diluted with CHC13 and filtered through Celite. The solvents were distilled off and the crude material was submitted for flash column purification in neutral alumina using 2% MeOH/CHCl3 to obtain pale yellow solid compound 5-(6-(4- methylpiperazin-l-yl)pyrazin-2-yl)-lH-pyrrolo[2,3-b]pyridine 125 in 20 mg quantity. The compound 125 was confirmed by 1HNMR and LCMS. 1H NMR (400 MHz, CDC13) delta: 8.96 (d, J=1.5Hz 1H), 8.55 (d, J=1.70Hz, 1H), 8.30 (s, 1H), 8.08 (s,lH), 7.35 (m, J=3.04, 1H), 6.60(m, J=1.95 1H), 3.75 (m, J=5.00, 4H), 2.58 (m, J=5.12, 4H), 2.38 (s , 3H); MS m/z 294.9 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRIEN PHARMAEUTICALS LLC; VANKAYALAPATI, Hariprasad; APPALANENI, Rajendra, P.; REDDY, Y., Venkata Krishna; WO2012/135631; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem