Related Products of 1320266-90-7,Some common heterocyclic compound, 1320266-90-7, name is 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, molecular formula is C9H10ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 8-chloro-3-isopropylimidazo[i,5-ajpyrazine (31 g, 158.5 mmol) indry THF (300 mL) at -78 C under nitrogen was added n-butyllithium (2.5 M in hexanes,82.4 mL, 206 mmol), keeping the internal temperature below -65 C. After stirring for 30 mma solution of iodine (56.3 g, 221.8 mmol) in THF (50 mL) was added dropwise over 10 mmkeeping the internal temperature below -65 C during addition. The resulting suspension wasstirred for 1 hour whilst warming to -10 C then the reaction mixture was quenched by theaddition of saturated aqueous NH4C1 and extracted with 2-methyltetrahydrofuran (x3). The combined organic extracts were washed with water and brine, dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by passage through a silica-gel pad, eluting with 0-20% EtOAc in DCM to give an orange solid, which was triturated with Et20 to givethe title compound 5B as a yellow solid (41.2 g, 81%). LC-MS: Rt = 1.29 mm, m/z = 322.0[M+Hj +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Chloro-3-isopropylimidazo[1,5-a]pyrazine, its application will become more common.
Reference:
Patent; OPTIKIRA LLC; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; KEENAN, Richard M.; BACKES, Bradley J.; MALY, Dustin J.; REYNOLDS, Charles; WHITTAKER, Ben; KNIGHT, Jamie; SUTTON, Jon; HYND, George; PAPA, Feroz, R.; OAKES, Scott, A.; (147 pag.)WO2019/46711; (2019); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem