Adding a certain compound to certain chemical reactions, such as: 1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1111638-10-8, Recommanded Product: 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
Step 4; A suspension of NaH (370 mg, 15.62 mmol) in DMF (15 mL) was cooled to 0 C. and treated with 4 (1.6 g, 10.41 mmol) dissolved in DMF (15 mL). The reaction mixture was stirred 20 min at 25 C. The reaction mixture was again cooled to 0 C., SEM-Cl (2.2 mL, 12.50 mmol) was added slowly, and allowed to stir at 25 C. for 2 h. TLC (20% EA/Hexane) indicates complete consumption of starting material. The solvent was distilled off and the residue was purified by column chromatography over silica gel (100-200 mesh) eluting with EtOAc/Hexane (5-10%) to provide 5 as a brown oily liquid (2.0 g, 67%). MS m/z (ES): 284 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael; US2011/59118; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem