Adding a certain compound to certain chemical reactions, such as: 642459-03-8, name is 6-Chloro-N-phenylpyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 642459-03-8, Computed Properties of C10H8ClN3
EXAMPLE 37 Preparation of [6- .-pyrazin-2-yl]-phenyl-amine To sodium hydride (50 mg, 1.25 mmol of a 60% dispersion in oil, 1.5 equiv) in DMSO (1 ml) was added a solution of 2-isopropylimidazole (138 mg, 1.25 mmol, 1.5 equiv) in DMSO (1 ml). The mixture was stirred 15 minutes and 6-chloro- (pyrazin-2-yl) -phenyl-amine (171 mg, 0.833 mmol, 1 equiv) was added as a solution in DMSO (1 ml). The mixture was heated to 80 C for 3 days then 130 C for a further 3 days. The title compound was purified by flash chromatography on silica (19 g, Si02), eluted with 10% MeOH-CH2Cl2, to afford 44 mg (19%); LCMS 2.06 min, iiilz [M+H] + 280.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloro-N-phenylpyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTEX TECHNOLOGY LIMITED; WO2004/4730; (2004); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem