Electric Literature of 19847-12-2, These common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The synthesis of 2-aminomethylpyrazine (2-AMPZ) was synthesized according to the method described below with reference to the method described in the literature (Japanese Patent Laid-Open No. 2001-894594). 2-cyanopyrazine is 1.05 g (10 mmol) of 2-cyanopyrazine using Aldrich reagent and 100 mg of 60 wt% Ni / SiO2 was charged into a SUS316 autoclave together with 20 mL of toluene and purged with argon gas.This was pressurized to 50 atm with hydrogen gas and stirred at 140 C. for 4 hours.The reaction solution was filtered and concentrated to quantitatively obtain 2-aminomethylpyrazine (2-AMPZ).
The synthetic route of 19847-12-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kanto Chemical Co., Inc.; Hokkaido University; Katayama, Takeaki; Tsutsumi, Kunihiko; Murata, Kunihiko; Ohkuma, Takeshi; Arai, Noriyoshi; (35 pag.)JP2019/11367; (2019); A;,
Pyrazine – Wikipedia,
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