1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
A solution of 3-chloro-5H-pyrrolo[2,3-b]pyrazine (20 g, 131 mmol) and DIPEA (37 mL, 212 mmol) in NMP (100 mL) was stirred with cooling provided by a salt/ice-bath. 2-(Trimethylsilyl)ethoxymethyl chloride (28.3 mL, 160 mmol) in NMP (40 mL) was added over a period of 5-10 mm. The cooling bathwas removed, and the mixture stirred overnight at RT. A 5% aq. LiCI solution (100 mL) was added. EtOAc (400 mL) was added and the mixture transferred to a 2 L separating funnel. The aqueous layer was removed and the EtOAc layer was washed with further 5% aq. LiCI solution (3 x 100 mL). The EtOAc layer was then washed successively with 0.5 M aq. KHSO4 (2 x 100 mL), sat. aq. Na2CO3 (50 mL), 5% aq. LiCI (50 mL) and sat. brine solution (100 mL). The EtOAc layer was dried (MgSO4), filteredand evaporated, to give a dark oil. The residue was purified by column chromatography on silica gel (gradient elution, 0-50%, EtOAc/petrol), to give the title compound (31.8 g), MS: [M+H] = 284.
The synthetic route of 1111638-10-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.; JOHNSON, Christopher Norbert; BUCK, Ildiko Maria; CHESSARI, Gianni; DAY, James Edward Harvey; FUJIWARA, Hideto; HAMLETT, Christopher Charles Frederick; HISCOCK, Steven Douglas; HOLVEY, Rhian Sara; HOWARD, Steven; LIEBESCHUETZ, John Walter; PALMER, Nicholas John; ST DENIS, Jeffrey David; TWIGG, David Geoffrey; WOODHEAD, Andrew James; (377 pag.)WO2019/167000; (2019); A1;,
Pyrazine – Wikipedia,
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