Adding a certain compound to certain chemical reactions, such as: 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-21-3, Safety of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
Diisopropylethylamine at 0 C(Trifluorobenzyl) -5,6,7,8-tetrahydro- [1, 3-methyl-5-oxazol- 2,4] triazolo [4,3-a] pyrazine hydrochloride (3.37 g, 14.8 mmol) in dichloromethane (80 mL).A solution of 1-hydroxybenzotriazole (2.40 g, 17.8 mmo 1)After stirring, continue stirring at 0 C for 10 minutes,Then 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (3.40 g, 17.8 mmol) was added portionwise.Stir overnight at room temperature.After the reaction,Washed with saturated aqueous sodium bicarbonate solution,Drying and passing through column chromatography (RhoEpsilon: EpsilonAlpha = 1: 1 to 100 Epsilon) gave a white solid 9 (7.2 g, 95.2% yield)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Biortus Biosciences Co.,Ltd; ZHANG, HAI JUN; ZHANG, SHUAI; BIAN, WANG DONG; (12 pag.)CN103483340; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem