Electric Literature of 1190927-25-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1190927-25-3 as follows.
To a solution of 3-morpholin-4-ylmethyl-1 /-/-indol-6-ol sodium salt (130 mg, 0.51 mmol) and 2-chloro-thiazolo[4,5-]pyrazine (70 mg, 0.41 mmol) in DMF (1.4 ml.) was added CS2CO3 (43 mg, 0.12 mmol) and the resulting suspension was stirred (rt, 16 h). The reaction mixture was filtered and the solid was rinsed with EtOAc. The reaction mixture was concentrated in vacuo. The resulting residue was purified via reverse phase HPLC to provide the title compound as a white powder (38.3 mg, 26%). MS (ESI): mass calculated for Ci8H17N5O2S, 367.1 ; m/z found, 368.1 [M+H]+. 1H NMR (600 MHz, CDCI3): 8.51 (d, J = 2.6, 1 H), 8.32 (d, J = 2.6, 1 H), 8.21 (s, 1 H), 7.83 (d, J = 8.6, 1 H), 7.45 (d, J = 2.2, 1 H), 7.21 (d, J = 2.3, 1 H), 7.12 (dd, J = 8.6, 2.2, 1 H), 3.75-3.69 (m, 6H), 2.51 (s, 4H).
According to the analysis of related databases, 1190927-25-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis; CHROVIAN, Christa, C.; ECCLES, Wendy; FOURIE, Anna, M.; GOMEZ, Laurent; GRICE, Cheryl, A.; KEARNEY, Aaron, M.; LANDRY-BAYLE, Adrienne, M.; LEE-DUTRA, Alice; SANTILLAN, Alejandro; TANIS, Virginia, M.; WIENER, John, J. M.; WO2010/132599; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem