Some common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,5-Dichloropyrazine-2-carbonitrile
j1416] Compound 356 from above was dissolved in 10 mE DMF. To it were added 3,5-dichloropyrazine-2-cabonitrile (250 mg, 1.42 mmol) and DIEA (500 IL, 2.84 mmol). The mixture was stirred at RT for 2 hours, diluted with 150 mE EtOAc, washed with water x3, dried, concentrated in vacuo, and subjected to silica flash column using 0 to 3% MeOR in DCM to isolate 3-chloro-54(2R,3R)-2-methyl-3-(3-methyl- 2-oxoimidazolidin-1 -yl)piperidin-1 -yl)pyrazine-2-carboni- trile (357, 200 mg, 42% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 313339-92-3, its application will become more common.
Reference:
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem