In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32111-21-0 as follows. Product Details of 32111-21-0
4.90 ml of tetrabutylammonium fluoride (1M solution in THF) are added to a solution of 500 mg (2.43 mmol) of iodopyrazine, 655 mg (3.64 mmol) of 4-fluoro-2-methoxy-1-prop-2-ynyloxy-benzene, 92 mg (0.48 mmol) of copper(l) iodide and 170 mg (0.24 mmol) ofbis(triphenylphosphine)palladium dichloride (Pd(PPh3)2CI2) in 16 ml of dioxane. The reactionmixture is stirred for 3 hours at 50C under an argon atmosphere and is then allowed to coolto 20C. The solvent is removed under reduced pressure and the crude product obtained ispurified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). Thedesired title compound is obtained as a beige solid having a melting point of 88C in a yieldof 412 mg (66 % of theory).Rf = 0.28 in ethyl acetate/petroleum ether 1/2;1H NMR (CDCI3): delta(ppm)= 3.87 (s, 3H); 4.98 (s, 2H); 6.56-6.69 (m, 2H); 7.04 (dxd, J=5.6 and8.8 Hz, 1H); 8.48 (d, J=2.5 Hz, 1H); 8.52 (dxd, J=1.3 and 2.5 Hz, 1H); 8.62 (d, J=1.3 Hz,1H).
According to the analysis of related databases, 32111-21-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2003/104206; (2003); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem