Reference of 5900-13-0, The chemical industry reduces the impact on the environment during synthesis 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, I believe this compound will play a more active role in future production and life.
General procedure: Azaheteroaryl halide (1 mmol), catalyst (0.005-0.05 mol %) and 1M aq. Na2CO3 (1.1 mL) were stirred in a mixture of H2O-EtOH(1:2, 5 mL). The arylboronic acid (1.1 mmol) was added to the above mixture and stirring was continued for required time at 60 C. After the requisite time, reaction mixture was diluted with ethyl acetate and the catalyst was separated by centrifugation. The centrifugate was dried over anhydrous sodium sulphate and evaporated. Then the product was analyzed by GC-MS or LC-MS.The solution was concentrated and chromatographed on a silicagel column with n-hexane-ethyl acetate (4:1) as the eluting solvent to give the coupled product. The product was confirmed by 1H and 13C NMR spectral analysis. The used catalyst was washed with water, ethanol and dichloromethane, and dried under vacuum before reuse.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-3-methoxypyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ganesamoorthy; Muthu Tamizh; Shanmugasundaram; Karvembu; Journal of Organometallic Chemistry; vol. 862; (2018); p. 76 – 85;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem