Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., Product Details of 56423-63-3
To a reaction flask were added compound 28 (100 mg, 0.189 mmol), 2-bromopyrazine (50 mg, 0.27 mmol), Pd(dppf)Cl2 (5 mg, 0.006 mmol) and sodium carbonate (60 mg, 0.558 mmol), 5 mL glycol dimethyl ether and 0.9 mL water were added, bubbled with nitrogen gas for 10 minutes, and the reaction was heated to 100 C in microwave and reacted for half an hour. After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatography to afford 41 mg of a product, yield: 45.3%. LC-MS(APCI): m/z = 480.3 (M+1)+. 1H NMR (400 MHz, CDCl3) delta 8.68 (s, 2H), 8.58 (s, 1H), 8.52 (s, 1H), 8.30 (s, 1H), 8.03 (s, 1H), 7.68 (d, J = 8.9 Hz, 2H), 7.22 (d, J = 8.5 Hz, 2H), 4.91 (d, J = 50.6 Hz, 1H), 4.35 (s, 1H), 3.68 (dd, J = 36.4, 23.2 Hz, 2H), 3.37 – 3.28 (m, 1H), 3.15 (d, J = 12.4 Hz, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (55 pag.)EP3553056; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem