Application of 13515-06-5,Some common heterocyclic compound, 13515-06-5, name is 5,6-Dimethylpyrazine-2-carboxylic acid, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5,6-dimethylpyrazine acid (248 mg, about 2 mmol, prepared as Example 2), 4-chloro-1-butanol (2.4mmol), EDCI (2.4mmol) and DMAP (0.2mmol) were added to dry methylene chloride (20mL), stir at room temperature for 12 hours, then dilute with dichloromethane (20mL), The saturated aqueous NaCl solution was washed, dried over anhydrous sodium sulfate, and purified by column chromatography to obtain an oily liquid. The hederagenin(236mg, 0.5mmol), K2CO3 (207mg, 1.5mmol) and oily liquid were added to DMF (20mL), The mixture was stirred at 85 C for 4 hours. It was then diluted with ethyl acetate (20 mL), washed with saturated aqueous NaCl solution, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography to obtain a white powder, H-17. Yield: 27% (after chromatograph with DCM / MeOH, 1% -2%) as a white powder, m.p .: 134.7 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dimethylpyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; Xinhuo Zhiyao (Beijing) Technology Co., Ltd.; Fang Kang; Guo Wenbo; Wang Penglong; Cheng Gang; (26 pag.)CN110964078; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem