These common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 109-08-0
EXAMPLE 13 4-(2-Pyrazinyl)-1-butene (1300) To a mixture of 15.6 g of sodium amide in 400 ml of ammonia was added dropwise 37.6 g of 2-methylpyrazine. The mixture was stirred for 2 hours and then 24.2 g of allyl bromide in 50 ml of ether was slowly added. This was stirred for 2 hours, 25 g of ammonium chloride added and the ammonia replaced by 500 ml of ether. 250 ml of water was added, the organic layer separated and the aqueous layer extracted twice with ether. The combined organic layers were then concentrated at reduced pressure. The residue was fractionated by distillation to give 20.5 g of product (1300), b.p. 96¡ã-7¡ã (25 mm). UV 2percent EtOH max: 268 (3.82), 273 (3.82). From the above distillation was also obtained 5.4 g of a second product, characterized as the bisalkylated compound, 4-(2-pyrazinyl)-1,6-beptadiene (1301), b.p. 122¡ã-3¡ã (24 mm). UV 10percent EtOH max: 269 (3.83), 273 (3.83).
The synthetic route of 2-Methylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Coca-Cola Company; US4638005; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem