Reference of 6164-79-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6164-79-0, name is Methyl 2-pyrazinecarboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Example 2; Methyl 2-methyl-3-(pyrazin-2-yl)-3-oxopropionate (formula 4). 1.2 L of tetrahydrofuran and 87.8 g (0.78 mole) of potassium t-butoxide were added to a reactor and cooled to 0C. 71.5 mL (0.74 mol) of methyl propionate was dropwise added to the reactor and stirred at 0C for 30 minutes. 60 g (0.434 mole) of the methyl pyrazine-2-carboxylate of Example 1 dissolved in 500 mL of tetrahydrofuran was dropwise added to the reactor for 30 minutes and stirred at a temperature of 20 to 25 C for 3 hours. 0.5 L of distilled water and 0.5 L of saturated ammonium chloride solution were added to the reaction solution and stirred for 30 minutes. The resultant reaction solution was concentrated to a volume of 1.0 L and then extracted with 1.0 L of methylenechloride. The resultant extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated to give 75.0 g of the titled compound as a dark brown viscous oil (yield 89.0%). NMR (S, CDCl3) : 1.50 (d, 3H), 3.65 (s, 3H), 4.70 (q, 1H), 8.60 (d, 1 H), 8.80 (d, 1 H), 9.21 (s, 1 H)
The synthetic route of Methyl 2-pyrazinecarboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CJ CORPORATION; WO2004/48369; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem