Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 109-08-0
A 2.5 M hexanes solution of n-BuLi (18.0 mL, 45 mmol) was added to a -78 0C THF solution (60 mL) of t-BuOK (5.1 g, 45 mmol) and diisopropylamine (6.3 mL, 45 mmol). After 5 min at -78 0C the yellow mixture was warmed to -40 0C. Neat methylpyrazine (2.7 mL, 30 mmol) was added and the mixture rapidly turned dark red. After 30 min at – 40 0C the mixture was cooled to -78 0C and neat allyl bromide (7.6 mL, 90 mmol) was added. After 30 min at -78 0C water was added and the mixture was partially concentrated to remove volatile organics. The resulting mixture was extracted with dichloromethane and the combined organics were dried (Na2SO4), concentrated, and purified via column chromatography to give 2.2 g of 2-but-3-enyl-pyrazine.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, J., Kent; LEONARD, Kristi; CHAKRAVARTY, Devraj; SHOOK, Brian, Christopher; WANG, Aihua; WO2010/45015; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem