Synthetic Route of 33332-25-1, A common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 30 2- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N-(5-METHYLSULFANYLMETHYL- PYRAZIN-2-YL)-PROPIONAMIDE [000205] A solution of methyl 5-chloropyrazine-2-carboxylate (5.00 g, 28.97 mmol) in acetonitrile (290 ML) was treated with a fresh bottle of silver (I) fluoride (11.00 g, 86.70 mmol). The reaction setup was covered with aluminum foil, and the reaction mixture was heated at reflux overnight. The mixture was filtered through a pad of celite, and the pad of celite was rinsed with acetonitrile. The filtrate was then concentrated in vacuo. Biotage chromatography (FLASH 40M, Silica, 25% ethyl acetate/hexanes) afforded 5-fluoro-pyrazine-2-carboxylic acid methyl ester (2.98 g, 66%) an off-white solid upon cooling to 0C. An analytical sample was obtained by trituration with petroleum ether to afford 5-fluoro-pyrazine-2-carboxylic acid methyl ester as a white crystalline solid: mp 55.6-56. 7C, EI-HRMS m/e calcd for C6HSFN202 (M 156.0335, found 156.0331.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem