These common heterocyclic compound, 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 8-Chloroimidazo[1,2-a]pyrazine
A vial containing tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate (263 mg, 1.09 mmol), 8- chloroimidazo[l,2-a]pyrazine (168 mg, 1.09 mmol) and triethyl amine (152 uL, 1.09 mmol) in THF (5.4 mL) heated to 50C for 4 hours. The reaction was cooled and concentrated to give the crude material, which was purified via MPLC (50-100% EtOAc/hexanes) to afford the title compound. LC-MS (357, m/z): 358 [M+l]+.
The synthetic route of 8-Chloroimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; PIO, Barbara; CHOBANIAN, Harry, R.; SHI, Zhi-Cai; DONG, Shuzhi; GUO, Yan; WALSH, Shawn, P.; GUO, Zhiqiang; FERGUSON, Ronald, D.; CATO, Brian; (114 pag.)WO2016/60941; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem