Synthetic Route of 313340-08-8, The chemical industry reduces the impact on the environment during synthesis 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide, I believe this compound will play a more active role in future production and life.
Preparation Example 39 To a mixture of 3-nitrophenyl disulfide (2 g) and N,N-dimethylformamide (60 mL) was added potassium carbonate (1.79 g), followed by stirring at room temperature for 2 minutes, and then 3,5-dichloro-6-ethylpyrazine-2-carboxamide (3.14 g) and formaldehyde sodium sulfoxylate (2.3 g), and water were added thereto, followed by stirring at room temperature for 2 hours. To the reaction mixture was added water, and the precipitated solid was collected by filtration, washed with water and diisopropyl ether, and then dried under reduced pressure to obtain 3-chloro-6-ethyl-5-[(3-nitrophenyl)sulfanyl]pyrazine-2-carboxamide (3.9 g) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dichloro-6-ethylpyrazine-2-carboxamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTELLAS PHARMA INC.; Matsuya, Takahiro; Kondoh, Yutaka; Shimada, Itsuro; Kikuchi, Shigetoshi; Iida, Maiko; Onda, Kenichi; Fukudome, Hiroki; Takemoto, Yukihiro; Shindou, Nobuaki; Sakagami, Hideki; Hamaguchi, Hisao; US2014/323463; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem