Reference of 41270-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Add 2-butanone (1440 ml) to the reaction flask,Sodium iodide (134.87g, 2.5 eq),2-chloro-5,6,-diphenylpyrazine (96 g, 1.0 eq),Nitrogen protection. Concentrated sulfuric acid (14.41 g, 0.4 eq) was added dropwise at room temperature. After the addition is completed, the temperature is raised toThe reaction was refluxed for 6 hours. After the reaction is completed,The reaction solution was concentrated to dryness. Add water (960ml),Dichloromethane (960 ml), liquid. The organic phase was concentrated to dryness filter,The solid is dried under reduced pressure,2-iodo-5,6,-diphenylpyrazine (88 g), yield 68.2%
The synthetic route of 5-Chloro-2,3-diphenylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Kesheng Pharmaceutical Research And Development Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Liu Huixin; Shen Junhui; Zhang Jicheng; Huang Luning; Tao Anping; An Jianguo; Chen Qian; Gu Hong; (10 pag.)CN109384734; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem