Some common heterocyclic compound, 15707-23-0, name is 2-Ethyl-3-methylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Ethyl-3-methylpyrazine
A mixture of 2-methyl-3-ethylpyrazine (22.35g, 183mmol), selenium dioxide (30g, 270mmol), and diatomaceous earth (30g) in dioxane (250ml) was heated at reflux for 18 hours. The mixture was allowed to cool and the solid material removed by filtration through diatomaceous earth. The filter pad was washed with methanol several times and the volatiles removed from the combined filtrate by evaporation. The residue was purified by chromatography on silica gel eluting with EtOAc/hexanes (0:100 increasing in polarity tol5:85) to give 3-ethylpyrazine-2-carboxaldehyde (3.0g, 12%); NMR Spectrum 1.22 (t, 3H), 3.19 (q, 2H), 8.78 (s, IH), 8.80 (s, IH), 10.10 (s, IH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15707-23-0, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/100461; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem