233278-56-3, name is 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
To a solution of (S)-N-((3 -(4-bromophenyl)-2-oxooxazolidin-5 – yl)methyl)acetamide (100.0 mg, 0.319 mmol), 5 ,6,7,8-tetrahydro-[ 1 ,2,4]triazolo[ 1 ,5-a]pyrazine (150.0 mg, 1.208 mmol) and Cs2CO3 (312.0 mg, 0.958 mmol) in 1,4-Dioxane (2 mL) was added 2nd generation ruphos precatalyst (12.4 mg, 0.0 16 mmol) under N2 atmosphere. The mixturewas stirred at 100C for 16 hours. The reaction mixture was concentrated to give a residuewhich was purified by reverse phase prep-HPLC to give (S)-N-((3-(4-(5,6-dihydro-[1,2 ,4]triazolo[ 1,5 -a]pyrazin-7(8H)-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide as solid. MS(ESI) m/z: 357.1 [M+Hj.
The synthetic route of 233278-56-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; YANG, Lihu; OLSEN, David B.; YOUNG, Katherine; SU, Jing; MANDAL, Mihir B.; SUZUKI, Takao; YOU, Lanying; (85 pag.)WO2017/66964; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem