Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6905-47-1, name is 2-Amino-6-methoxypyrazine, A new synthetic method of this compound is introduced below., Safety of 2-Amino-6-methoxypyrazine
Step 28.1 : (preparation of a compound of formula (Clll)) 1 -(6-Methoxypyrazin-2-yl)-3-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2- yl)phenyl]urea A mixture of 350 mg (1.60 mmol) of 4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2- yl)phenylamine and 1 .35 ml (9.59 mmol) of triethylamine in 10 ml of DCM is added, under nitrogen, to a solution of 474.07 mg (1.60 mmol) of triphosgene in 30 ml of DCM. The mixture is stirred for 30 minutes at room temperature, followed by addition of 1 g (7.99 mmol) of 6-methoxypyrazin-2-amine. The resulting mixture is stirred for 2 hours at room temperature. Water is added and the product is extracted with DCM. The solution is dried over MgS04 and then filtered. The filtrate is evaporated under reduced pressure and the residue is then chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0 v/v) up to (96/4 v/v). The solvent is evaporated off under reduced pressure. The residue is taken up in ethyl acetate and washed three times with 1 N hydrochloric acid solution and then with saturated NaCI solution. The resulting solution is dried over MgSCv 167 mg of 1 -(6-methoxypyrazin-2-yl)-3-[4-(4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolan-2-yl)phenyl]urea are obtained. LC/MS (method E): M+H+ = 371 ; Tr = 2.46 min
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SANOFI; BRAUN, Alain; CRESPIN, Olivier; FORICHER, Yann; MARCINIAK, Gilbert; MUZET, Nicolas; NICOLAI, Eric; PASCAL, Cecile; VIVET, Bertrand; VIVIANI, Fabrice; WO2013/111106; (2013); A1;,
Pyrazine – Wikipedia,
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