Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., name: Pyrazin-2(1H)-one
Weigh the pyrazin-2(1H)-one (481 mg, 5 mmol) in a 50 mL single-mouth bottle. Add anhydrous N,N-dimethylformamide (6 mL), Sodium hydride (240 mg, 6 mmol, 60%) was added and the mixture was stirred at room temperature. Weighed after 20 minutes Ethyl 2-bromoacetate (1.0 g, 10.0 mmol, Dissolved in 4 mL of anhydrous N,N-dimethylformamide) and added dropwise to the reaction flask. After the addition was completed, the reaction was stirred at room temperature overnight. Stop the reaction, The reaction was quenched by dropwise addition of water (2 mL). Add water (30mL), Extracted with ethyl acetate (30 mL ¡Á 3), Combine the organic phase to concentrate, The residue was purified by column chromatography ( petroleum ether / ethyl acetate (v / v) = 1 / 1) The title compound was obtained as a pale yellow liquid (360 mg, 40%).
The synthetic route of 6270-63-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Xu Tengfei; Jin Chuanfei; Zhong Wenhe; Xue Yaping; (45 pag.)CN109761892; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem