Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20737-42-2, name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 20737-42-2
Example 4 (6-Chloro-lH-indol- -yl)[2-[(4-fluorobenzyl)amino]pyrazin-3-yl]methanone 3-Chloro-2-pyrazinecarbonyl chloride. 3-Hydroxy-2-pyrazinecarboxylic acid (455 mg, 3.27 mmol) in POCI3 (6 mL) was treated with 3 drops of pyridine and heated to reflux for 2h. Once at rt, the reaction was cone, to dryness. The residue was dissolved in toluene and cone, in vacuo and then triturated with hexanes (4 x 10 mL). The hexanes washes decanted, combined and cone. This material in toluene (10 mL) containing 1 drop of DMF was treated with neat SOCl2 (2 mL) and heated at reflux for 3 h. The mixture was decanted and cone, in vacuo. The residue was dissolved in toluene and cone, to give 355 mg of a purple liquid that solidified on standing.
The synthetic route of 20737-42-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HOGENKAMP, Derk; WO2013/169907; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem