These common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 75907-74-3
The obtained 2-hydroxymethyl-3,5,6-trimethylpyrazine (152 mg, 1 mmol) was dissolved in a THF solution, and phosphorus tribromide (410 mg, 1.5 mmol) was added dropwise under an ice bath condition. The reaction was stirred at 0 C for 30 minutes, and the reaction was quenched by adding saturated sodium bicarbonate. Dilute with 50ml of ethyl acetate, and wash the organic layer three times with saturated brine, dry over anhydrous sodium sulfate, filter, and concentrate, silica gel column chromatography (petroleum ether: ethyl acetate = 2: 1)2-bromomethyl-3,5,6-trimethylpyrazine was obtained as a light yellow solid (182 mg, 85%).
The synthetic route of (3,5,6-Trimethylpyrazin-2-yl)methanol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Taizhou College; Mu Yi; Zhang Rui; Liu Jing; Gao Xinxing; (8 pag.)CN110483419; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem