In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446286-94-8, name is 5-Bromo-N,N-dimethylpyrazin-2-amine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C6H8BrN3
EXAMPLE 2 P N-(4-(5-(dimethylamino) pyrazin-2-ylsulfonyl) benzyl) imidazo [1, 2-al pyridine-6-carboxamidea. N-f4-f5-fdimethylamino)pyrazin-2-ylsulfonyl)benzyl) acetamide:The mixture of XANTPHOS (0.573 g, 0.990 mmol), Cs2C03 (6.45 g, 19.80 mmol), Pd2(dba)3 (0.453 g, 0.495 mmol),4-(acetamidomethyl)benzenesulfinic acid, sodium salt (3.51 g, 14.85 mmol), 5-bromo-N,N-dimethylpyrazin-2-amine (2 g, 9.90 mmol) in Toluene (50 ml) was degassed and heated to 120 C for overnight. Cooled to RT, added EtOAc, washed with water, dried and concentrated, The Biotage purification afforded 1.6g of the target compound (48%).1HNMPv (CDC13): delta 8.75(s, 1H). 8.03 (s, 1H), 7.87 (d, 2H), 7.38 (d, 2H), 6.11 (b, 1H), 4.45 (d, 2H), 3.21 (s, 6H), 2.16 (s, 3H).
The synthetic route of 446286-94-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORMA THERAPEUTICS, INC.; GENENTECH, INC.; BAIR, Kenneth, W.; BAUMEISTER, Timm; BUCKMELTER, Alexandre, J.; CLODFELTER, Karl, H.; DRAGOVICH, Peter; GOSSELIN, Francis; HAN, Bingsong; LIN, Jian; REYNOLDS, Dominic J.; ROTH, Bruce; SMITH, Chase, C.; WANG, Zhongguo; YUEN, Po-Wai; ZHENG, Xiaozhang; WO2012/31197; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem