In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35808-40-3, name is 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 35808-40-3
In accordance with the same process as in Example 41, 190 mg (yield: 40%) of crude crystals of the title compound were obtained from 477 mg (1.8 mmol) of 5-(3,4,5-trimethoxyphenyl)penta-(2E,4E)-dienoic acid and 102 mg (0.75 mmol) of pyrido[2,3-b]-1,2,3,4-tetrahydropyrazine(1).. The crude crystals were recrystallized from ethanol to obtain pale yellow fine needles. Melting point: 183-185 C. 1H-NMR (DMSO-d6, 120 C.) delta: 3.72(s,3H), 3.73(s,3H), 3.81(s,6H), 3.81(s,6H), 4.00(s,4H), 6.58(d,J=14.7 Hz,1H), 6.83(s,2H), 6.83(s,2H), 6.88-7.05(m,5H), 7.21(dd,J=8.1,4.8 Hz,1H), 7.35(ddd,J=14.7,8.9,1.1 Hz,1H), 7.39(ddd,J=14.7,8.9,1.1 Hz,1H), 8.02(dd,J=8.1,1.7 Hz,1H), 8.19(dd,J=4.8,1.7 Hz,1H).
The synthetic route of 35808-40-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kowa Co., Ltd.; US6340682; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem