Synthetic Route of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2.0 g methylpyrazine and 1.8g trichloro isocyanuric acid in 30 ml chloroform was refluxed for 18 hours. The resulting solids were filtered off and the solvent evaporated. The residue was dissolved in 7 ml DMF, 160 mg (0.62 mmol) of triazinone (see example 38) and 1 ml DBU were added and stirred for 18 hours. The crude product was purified after20 evaporation of the solvent, using flash chromatography (50 g silica gel, ethyl acetate:chloroform 85/15). The product fractions were combined and the solvent removed under vacuum. The product was crystallized from chloroform: ethyl acetate to give 130 mg of a white solid with the following properties: MP: 229-2310C; 1H NMR (300 MHz, CDCl3) delta 8.79 (IH, s) 8.71 (IH, s), 8.51 (2H, s), 7.85 (IH, s), 5.78 (2H, s), 5.61 (IH, t, J = 6.0 Hz),-25 3.97-3.88 (IH, m), 3.74-3.66 (IH, m) and 2.60-1.95 ppm (4H, m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/85505; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem