Some common heterocyclic compound, 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H4ClN3
To a solution of the product form step 2 (82.9 mg, 0.29 mmoi) in DMF (5 mL) was added NaH (14.0 mg 0.35 mrnol, 60 wt% in oil) at RT. The mixture was stirred at RT for 30 minutes, then 8.-chloroirnidazo[I2.-a]pyrazine (45.9 mg, 0.30 mmol) was added. The resulting mixture was heated to 40C for 2.5 hr. After cooling to RT, the mixture was poured into water (5 mL) and extracted with EtOAc (5 mL x 3). The combined organic layer was washed with brine, driedover MgSO4, filtered and concentrated in vacuo. The residue was purified by Prep-HPLC to afford the title compound (60 mg) as a brown solid. LRMS mz (M+H) 404,1 found, 404.1 required.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 69214-33-1, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem