Electric Literature of 1260812-97-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260812-97-2, name is 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To anydrous ethanol (60 mL) were added2-bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine (6.00 g, 28 mmol), ammonium formate (27.00 g,428 mmol) and 10% Pd/C (6 g). The mixture was refluxed for 5 hours under nitrogen protection.The reaction mixture was filtered through a celite pad, concentrated in vacuo to remove thesolvent, and the residue was purified by silica gel column chromatography (PE/EA (v/v) =411-211) to give the title compound as a yellow solid (3.10 g, 82 %).MS (ESI, pos. ion) m/z: 134.2 [M+Ht.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem