Related Products of 16298-03-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
3-Aminopyrazine-2-carboxylic acid methyl ester (3.0 g, 20 mmol) was suspended in tetrahydrofuran (100 ml) under a nitrogen atmosphere and cooled to 0 C. Lithium aluminium hydride as a 1.0M solution in tetrahydrofuran (20 ml, 20 mmol) was added dropwise over 30 minutes whereupon the solution was stirred for another 30 minutes. Saturated aqueous ammonium chloride solution (100 ml) was carefully added (evolution of gas) and the resulting mixture acidified (pH 1) with 4M hydrochloric acid, shaken (5 minutes) and then basified again (pH 10) with saturated aqueous sodium hydrogen carbonate solution. The mixture was extracted with diethyl ether (3 x 150 ml) and the combined organic phase dried (MgS04) and concentrated in vacuo. The yellow oily residue was applied to column chromatography (silica gel/dichloromethane/methanol) and the first fraction was concentrated in vacuo to yield the aldehyde as pale yellow crystals (689 mg, 28 percent). 1H-NMR (400 MHz, DMSO-d6): delta 9.90 (1H, s); 8.31 (1H, d); 8.02 (1H, d); 7.67 (2H, bs). APCI-MS m/z: 124 (MH+).
The chemical industry reduces the impact on the environment during synthesis Methyl 2-aminopyrazine-3-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; AstraZeneca AB, AstraZeneca AB; WO2004/16600; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem