In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59303-10-5 as follows. COA of Formula: C5H5ClN2
A mixture of 5-(4-methanesulfonyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (50 mg), 2-chloro-5-methylpyrazine (30 mg), and cesium carbonate (91 mg) in dimethylsulfoxide (1 mL) is heated to 150 C. in a microwave oven. After cooling to room temperature the reaction mixture is diluted with water and extracted with ethyl acetate. The combined extracts are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is chromatographed on silica gel (ethyl acetate/methanol 98:2?97:3). The crude product is triturated with a small amount of methanol and the precipitate is filtered off, washed with diethyl ether, and dried to give the title compound. LC (method 5): tR=1.08 min; Mass spectrum (ESI+): m/z=451 [M+H]+.
According to the analysis of related databases, 59303-10-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; LANGKOPF, Elke; NOSSE, Bernd; US2013/18030; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem