Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H3Br2N3
Step 1: synthesis of 3-amino-6-bromopyrazine-2-carbonitrile (14)A solution of copper(i) cyanide (1.20 g, 13.42 mmol) and sodium cyanide (0.658 g, 13.42 mmol) in DMF (10 mL) was heated to 125C. 2-amino-3,5-dibromo pyrazine (2.61 g, 10.32 mmol) was added in portions. The reaction was stirred at 125C, and after 5h quenched in ice cold NaHC03 solution. The black precipitate was filtrated off and the filtrate was extracted (3x) with EtOAc. The organic layer was washed with brine, dried and evaporated. Purification by chromatography (CH2CI2) gave pure 3- amino-6-bromopyrazine-2-carbonitrile 14 (1.38 g, 67.2 %). 1H-NMR (400 MHz, CDC13) 5.29 (br s, 2H), 8.30 (s, 1H). (m/z) = 199 and 201 (M+H)+.
According to the analysis of related databases, 24241-18-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; N.V. ORGANON; FOLMER, Brigitte, Johanna, Bernita; MAN, de, Adrianus, Petrus, Antonius; GERNETTE, Elisabeth, Sophia; CORTE REAL GONCALVES AZEVEDO, Rita; IBRAHIM, Hemen; WO2011/147764; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem