76537-18-3, name is 3-Bromo-5-chloropyrazin-2-amine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H3BrClN3
3-Bromo-5-chloropyrazin-2-amine (200 mg, 0.96 mmol), triethylamine (290 mg, 2.88 mmol), cuprous iodide (5 mg, 0.33 mmol) and bis(triphenyl) Palladium dichloride (13 mg, 0.02 mmol) was dissolved in tetrahydrofuran (5 mL).The reaction solution was stirred at room temperature.Then, trimethylethynyl silicon (0.15 mL, 1.06 mmol) was slowly added dropwise to the above reaction solution.After the completion of the dropwise addition, the obtained reaction liquid was transferred to a condition of 55 C to continue the reaction for 1 hour. After the reaction system is cooled to room temperature,The reaction solution was diluted with ethyl acetate (50 mL) and filtered.The filtrate was concentrated under reduced pressure.The residue obtained was subjected to silica gel column chromatography(PE/EA(nu/nu) = 30/1) purified,The title compound was obtained as a pale yellow solid (208 mg,96%).
The synthetic route of 76537-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Wang Yejun; Yi Kai; Lei Yibo; Zhang Yingjun; S ¡¤geerdeman; Yan Huan; Nie Biao; Xu Juan; Chen Jianping; Chen Yunfu; Zhang Weihong; Cheng Lijun; Ye Weiliang; (197 pag.)CN110117285; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem