Synthetic Route of 16298-03-6,Some common heterocyclic compound, 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, molecular formula is C6H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: Synthesis of Intermediate B’ as described in the general scheme: 2-amino-3-amidopyrazine A mixture of A’ (270 g, 1.763 M), methanol (1.05 L) and liq. Ammonia (25%) (1.68 L) is stirred at 30 C. for 24 hrs. The resulting solid is separated by filtration, washed with water (210 mL*2) and dried at 50-55 C. under vacuum to afford B’, used in the next step without further treatment.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-aminopyrazine-3-carboxylate, its application will become more common.
Reference:
Patent; WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian; US2011/118269; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem