Electric Literature of 17231-51-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17231-51-5 as follows.
Step 1 [0188] A 50 mL RBF equipped with magnetic stir bar was charged with 1.0 g (1.0 eq.) Bromo amine, 1 .6 g (2.2 eq.) methyl Iodide, and 3.7 g (2.2 eq.) CsC03 in 25 ml DMF. The reaction was stirred at RT. The reaction mixture got dark and was let to stir overnight. LC/MS looks like previous runs. The reaction was partionned between EA and aq. Citric. The organics were washed with satd. bicarb, brine, dried and concentrated in vacuo to crude. Purification was done by Flash Chromatography (20 – 50 % EA-H). The fractions containing visible yellow product (even if some had some long wave impurities) were combined and concentrated then vacuum dried to afford 940 mgs of crystalline solid.
According to the analysis of related databases, 17231-51-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MALLINCKRODT LLC; FRESKOS, John, N.; WO2013/39851; (2013); A1;,
Pyrazine – Wikipedia,
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