In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: 6-Chloropyrazine-2-carboxylic acid
6-Ch[oropyrazine-2-carboxy[ic acid [CAS RN: 23688-89-3] (218 mg, 1.38 mmo[,1.0 eq) was disso[ved in 3 mL THF, and CDI (224 mg, 1.38 mmo[, 1.0 eq) wasadded. Then, the reaction mixture was heated to 70C for 2 h. Then, 1-(2-f[uoroethy[)piperidin-4-amine [CAS RN: 947263-70-9] (208 mg, 1.42 mmo[,1.03 eq) and triethy[amine (0.40 mL, 2.85 mmo[, 2.06 eq) as a so[ution in 2 mLTHF were added. The reaction mixture was heated to 70C for 1 h and was a[[owed to stand at rt for 1 day. Subsequent[y, the reaction mixture was partitioned between ethy[ acetate and water. The aqueous phase was extracted with ethy[ acetate and the combined organic [ayers were washed with brine. The phases were separated by the use of a Whatman fi[ter, the vo[ati[ecomponents were removed in vacuo and the crude materia[ was purified via preparative MPLC (Biotage Iso[era; 25 g SNAP cartridge: ethy[ acetate -> ethy[ acetate/ethanol. 4/1) to give 100 mg (24% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.52 mm; MS (EI0): m/z = 287 [M+H].
The synthetic route of 23688-89-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem