Adding a certain compound to certain chemical reactions, such as: 74290-69-0, name is 5-Bromo-6-methylpyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74290-69-0, Safety of 5-Bromo-6-methylpyrazin-2-amine
Step 1: Synthesis of 1-38.1To a solution of 1-35.4 (495 mg, 2.39 mmol) in THF (5ml) in a microwave vial is added hexamethyldistannane (0.55 ml, 2.64 mmol) followed by bis(triphenylphosphine)palladium(II) chloride (168 mg, 0.239 mmol). The reaction mixture is degassed with argon, capped, and stirred at 85 C for 16 hrs. R-32 (450 mg, 2.39 mmol) is added followed by tetrakis(triphenylphosphine)palladium (0) (276 mg, 0.239 mmol). The reaction vessel is degassed with argon, then capped and heated at 85 C for 16 hours. The reaction mixture is passed through a plug of Celite and rinsed with DCM. The filtrate is concentrated in vacuo and purified by flash chromatography (Si02, 0-5% MeOH/DCM) to afford the title intermdiate (160 mg); m/z 281.3 [M+l]
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-6-methylpyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40137; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem