Discovery of 41110-34-3

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 5-methylpyrazine-2-carboxylate

Ethyl 5-methyl-2-pyrazinecarboxylate (10.0 g, 60.18 mmol), benzoyl peroxide (1. 46 g, 6. 02 mmol) and N-bromo succinimide (11. 78 g, 66. 19 mmol) in 80 mL CCl4 was heated to reflux while a 75W tungsten lamp was shining on the reaction mixture. After 4h the reaction mixture was cooled and the precipitate filtered off. The red filtrate was concentrated and the residue redissolved in EtOAc and washed with sat’d NaHC03, 5% Na2S203, brine and the organics dried (Na2SO4), filtered and concentrated. Chromatography on silica gel using 1: 1 Hexanes: EtOAc eluted the product. After concentration the title compound (6.64 g, 27.08 mmol, 45% yield) was isolated as a yellow oil :’H NMR (CDC13, 400 MHz) 8 9.22 (s, 1H), 8.80 (s, 1H), 4. 58 (s, 2H), 4.49 (dd, J= 14.3, 7.1 Hz, 2H), 1.43 (t, J= 7.2 Hz, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/76440; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem