Adding a certain compound to certain chemical reactions, such as: 74290-69-0, name is 5-Bromo-6-methylpyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74290-69-0, Computed Properties of C5H6BrN3
Compound 9 was prepared by reacting compound 7 (3.18 g;11 mmol) with compound 8 (1.88 g; 10 mmol) in the presence of Pd(PPh3)4 (250 mg) and Na2CO3 (6.36 g; 60 mmol) in THF (120 mL containing10% water) for 12 h at 343 K. Compound 9 was purified bycolumn chromatography on silica gel using petroleum ether/ethyl acetate(15:1, v/v) as eluent. A yellow solid was obtained with 90% yield.M.p.: 454-455 K. 1H NMR (400 MHz, DMSO-d6 TMS), delta (ppm): 7.78 (s,1H), 7.43 (d, J 8.4 Hz, 2H), 7.30 (t, J 7.6 Hz, 4H), 7.04 (d,J 8.0 Hz, 4H), 7.03 (d, J 5.2 Hz, 2H), 6.99 (d, J 8.4 Hz, 2H), 6.35 (s, 2H), 2.36 (s, 3H). 13C NMR (101 MHz, DMSO-d6, TMS) delta (ppm):153.6, 147.3, 147.1, 146.1, 139.4, 133.6, 129.7, 129.5, 128.8, 124.0,123.0, 122.5, 22.6. ESI-MS (ESI, m/z): [M] calcd of C23H20N4, 352.1;found, 353.2, [M H].
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Reference:
Article; Shi, Fu; Cui, Shiqiang; Liu, Hongling; Pu, Shouzhi; Dyes and Pigments; vol. 173; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem