Application of 95-89-6, The chemical industry reduces the impact on the environment during synthesis 95-89-6, name is 3-Chloro-2,5-dimethylpyrazine, I believe this compound will play a more active role in future production and life.
[1-ETHYLPROPYLAMINE] (1.0 mmol) followed by sodium tert-butoxide (1.25 mmol) is added to a mixture of 2-chloro-3,6-dimethylpyrazine (0.83 mmol), tris (dibenzylideneacetone) dipalladium [(0)] (2 mol%), and BINAP (6 mol%) in ethyleneglycol dimethyl ether (2 mL) under nitrogen. The mixture is stirred at 70-80C for 2.5 hours, diluted with aqueous ammonium chloride, and extracted 1: 1 hexane-Et20. Combined extracts are dried (sodium sulfate), filtered, concentrated, and chromatographed on silica gel (10: 1 to 4: 1 hexane-EtOAc eluent) to give the aminopyrazine.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2,5-dimethylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEUROGEN CORPORATION; WO2004/18437; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem