Adding a certain compound to certain chemical reactions, such as: 937669-80-2, name is 3-Bromopyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937669-80-2, COA of Formula: C5H3BrN2O2
In a 500 mL three-necked flask, 3-bromopyrazine-2-carboxylic acid (20.3 g, 0.1 mol) was dissolved in 200 ml of methanol, and 20 ml of concentrated sulfuric acid having a concentration of 98 wt% was added dropwise to the reaction solution.After stirring at room temperature for 12 hours, the reaction was quenched, the reaction was quenched with EtOAc (EtOAc)EtOAc.A mixed solvent of petroleum ether/dichloromethane (volume ratio of 2/1) was used as a rinse agent, and the yield was 83%.
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Reference:
Patent; South China Xietong Chuangxin Institute; Ying Lei; Hu Liwen; Huang Fei; Cao Yong; (22 pag.)CN108218891; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem