Reference of 4774-14-5,Some common heterocyclic compound, 4774-14-5, name is 2,6-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 4; 6-Chloro-N-phenylpyrazin-2-amine A solution of 2,6-dichloropyrazine (1 g, 6. 7 mrnol) and anitine (1. 25 g, 13.4 mmol) in ethoxyethanol (20 mE) containing DIPEA (2.5 mL, 13. 4 minor) was heated at reflux for 3 days under Na. The solution was concentrated under reduced pressure and the residue dissolved in EtOAc (50 mL) and washed successively with H20 (50 mL), 1M HC1 (2 x 50 mL), H20 (50 mL) and brine (50 mL). After drying (Na2SO4) the solvent was removed under reduced pressure and the residue chromatographed cluting with EtOAc-hexane (20:80-50:50) to separate pure product from the lower fractions (230 mg, 17%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dichloropyrazine, its application will become more common.
Reference:
Patent; CYTOPIA RESEARCH PTY LTD; WO2005/66156; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem