Adding a certain compound to certain chemical reactions, such as: 59489-71-3, name is 2-Amino-5-bromopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59489-71-3, Recommanded Product: 2-Amino-5-bromopyrazine
2-Amino-5-bromo-pyrazine (20) (1,170mg, 6.72mmol), was dissolved in iodomethane (CH3I) (1.2ml, 19.5mmol) in tetrahydrofuran (THF) (100ml). The solution was cooled to 0 C., 60% sodium hydride (NaH) (1.5g, 37.5mmol) was added slowly and the mixture was stirred for 5 hours. A small amount of methanol was added to the reaction mixture, an excess of iodomethane, to decompose sodium hydride. Followed by water (10ml) was added and extracted with ethyl acetate (3 ¡Á 200ml). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by column chromatography [silica gel 48.5 g; hexane – ethyl acetate (1: 1)] and purified by, 2-dimethylamino-5-bromo-pyrazine (21) (1,096mg, 5.4mmol , 80%) as a pale yellow powdered solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-bromopyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY OF ELECTRO-COMMUNICATIONS; MAKI, SHOJIRO; NIWA, HARUKI; (25 pag.)JP2015/193584; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem